Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese

  title={Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese},
  author={Takuya Matsushita and Noriko Isobe and Takeshi Matsuoka and Nan Shi and Yuji Kawano and XM Wu and Takashi Yoshiura and Yuzo Nakao and Takaaki Ishizu and JI Kira},
  journal={Multiple Sclerosis},
  pages={834 - 847}
Background Antibodies to aquaporin-4 (AQP4) are found in a fraction of Japanese opticospinal multiple sclerosis (OSMS) patients. However, it remains unknown whether anti-AQP4 antibody-positive and negative OSMS patients possess an identical disease. Objective The objective of the current study was to clarify immunological differences between the two groups of patients. Methods We studied the serum antibody titers against AQP4 in 191 patients with idiopathic central nervous system demyelinating… 

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