Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse.

@article{Chan2012Aquaporin4AC,
  title={Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse.},
  author={Koon Ho Chan and Rongzhen Zhang and Jason SC Kwan and Vivian Yawei Guo and Philip Wl Ho and Joanne M.W. Ho and Andrew Chi Yuen Chu},
  journal={Journal of neuroimmunology},
  year={2012},
  volume={245 1-2},
  pages={32-8}
}
BACKGROUND Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4 autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and relapse of NMO are uncertain. OBJECTIVE Study the pathogenicity of AQP4 Ab in the absence of complement activation. METHODS Female C57BL/6N mice (human IgG cannot activate mouse complements) pretreated with complete Freund's adjuvant (CFA, day 0) and… CONTINUE READING
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