Aquaporin-4 astrocytopathy in Baló’s disease

  title={Aquaporin-4 astrocytopathy in Bal{\'o}’s disease},
  author={Takeshi Matsuoka and Satoshi Suzuki and Toru Iwaki and Takeshi Tabira and Artemio T. Ordinario and Jun-ichi Kira},
  journal={Acta Neuropathologica},
Baló’s concentric sclerosis (BCS) is considered to be a rare variant of multiple sclerosis and characterized by alternating rings of demyelinated and preserved myelin layers. The mechanism underlying BCS remains to be elucidated. Recently, occurrence of concentric rings of Baló was described in the brainstem of a patient with neuromyelitis optica (NMO). Because selective loss of aquaporin-4 (AQP4) and vasculocentric deposition of complement and immunoglobulins are characteristic in NMO, we… CONTINUE READING


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Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis.

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