Aquaporin-4 astrocytopathy in Baló’s disease

@article{Matsuoka2010Aquaporin4AI,
  title={Aquaporin-4 astrocytopathy in Bal{\'o}’s disease},
  author={Takeshi Matsuoka and Satoshi O. Suzuki and Toru Iwaki and Takeshi Tabira and Artemio T. Ordinario and Jun-ichi Kira},
  journal={Acta Neuropathologica},
  year={2010},
  volume={120},
  pages={651-660}
}
Baló’s concentric sclerosis (BCS) is considered to be a rare variant of multiple sclerosis and characterized by alternating rings of demyelinated and preserved myelin layers. The mechanism underlying BCS remains to be elucidated. Recently, occurrence of concentric rings of Baló was described in the brainstem of a patient with neuromyelitis optica (NMO). Because selective loss of aquaporin-4 (AQP4) and vasculocentric deposition of complement and immunoglobulins are characteristic in NMO, we… 
Reappraisal of Aquaporin‐4 Astrocytopathy in Asian Neuromyelitis Optica and Multiple Sclerosis Patients
TLDR
The present and previous findings suggest that antibody‐independent AQP4 loss can occur in heterogeneous demyelinating conditions, including NMO, Baló's disease and MS.
Astrocytopathy in Baló’s disease
  • J. Kira
  • Medicine
    Multiple sclerosis
  • 2011
TLDR
It is proposed that AQP4 astrocytopathy, in the absence of anti-AQP4 antibody, is characteristic of Baló’s disease and should be tested in future experimental studies.
[Astrocytopathy in neuromyelitis optica, multiple sclerosis and Baló's disease].
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) while neuromyelitis optica (NMO) is an inflammatory disease of the CNS that selectively affects the optic nerves
Loss of connexins might cause extensive demyelination in Baló's disease
TLDR
It is shown, for the first time, that Bal o’s disease is characterized by extensive loss of Cx and AQP4, and a lack of autoantibodies against CX and AQp4, which is possibly related to disease aggressiveness for both conditions.
Connexin pathology in acute multiple sclerosis, Baló's disease and neuromyelitis optica
TLDR
It is suggested that Cx43 astrocytopathy can occur in MS, BD and NMO and might be associated with disease aggressiveness and distal oligodendrogliopathy, not only in BD, but also MS and N MO.
Evidence of aquaporin involvement in human central pontine myelinolysis
TLDR
This report is the first to establish astrocytic AQP loss in a subset of human CPM cases and suggests AQP1 and AQP4 may be involved in the pathogenesis of CPM.
Extensive loss of connexins in Baló’s disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte–oligodendrocyte/myelin interaction
TLDR
Investigation of the relationship between astrocytopathy and demyelination in Baló’s disease finds loss of Cx43 and AQP4 in the presence of other oligodendrocyte/myelin proteins at the leading edges suggests the possibility that auto-antibody-independent astroicytopathy may contribute to disease pathology via the disruption of astroCyte–oligodend rocyte-specific protein-myelin interactions.
Connexin 43 Astrocytopathy Linked to Rapidly Progressive Multiple Sclerosis and Neuromyelitis Optica
TLDR
It is suggested that autoantibody-independent astrocytic Cx43 loss may relate to disease aggressiveness and distal oligodendrogliopathy in both MS and NMO.
[Connexin astrocytopathy and novel therapeutic strategy targeting connexin hemichannels in demyelinating disease].
  • K. Masaki
  • Medicine
    Rinsho shinkeigaku = Clinical neurology
  • 2012
TLDR
The findings indicate that disruption of Cx gap junction and preferential MAG loss could occur in MS, BD and NMO, and could be a common denominator for demyelinating disorders.
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