Aquaporin-4 as a molecular partner of cystic fibrosis transmembrane conductance regulator in rat Sertoli cells.

@article{Jesus2014Aquaporin4AA,
  title={Aquaporin-4 as a molecular partner of cystic fibrosis transmembrane conductance regulator in rat Sertoli cells.},
  author={Tito T Jesus and Raquel Bernardino and Ana Luiza Raffaini Duarte Martins and Ros{\'a}lia S{\'a} and M{\'a}rio Sousa and Marco G Alves and Pedro F Oliveira},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={446 4},
  pages={1017-21}
}
Sertoli cells (SCs) form the blood-testis barrier (BTB) that controls the microenvironment where the germ cells develop. The cystic fibrosis transmembrane conductance regulator (CFTR) plays an essential role to male fertility and it was recently suggested that it may promote water transport. Interestingly, Aquaporin-4 (AQP4) is widely expressed in blood barriers, but was never identified in SCs. Herein we hypothesized that SCs express CFTR and AQP4 and that they can physically interact. Primary… CONTINUE READING

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