Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis.

@article{Waters2008Aquaporin4AI,
  title={Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis.},
  author={Patrick Waters and Sven Jarius and Edward Littleton and M Isabel Leite and Saiju Jacob and Bryony Gray and Ruth Geraldes and Thomas R. Vale and Anu Anna Jacob and Jacqueline A Palace and Susan Maxwell and David Beeson and Angela Vincent},
  journal={Archives of neurology},
  year={2008},
  volume={65 7},
  pages={
          913-9
        }
}
  • Patrick Waters, Sven Jarius, +10 authors Angela Vincent
  • Published in Archives of neurology 2008
  • Medicine
  • BACKGROUND There is increasing recognition of antibody-mediated immunotherapy-responsive neurologic diseases and a need for appropriate immunoassays. OBJECTIVES To develop a clinically applicable quantitative assay to detect the presence of aquaporin-4 (AQP4) antibodies in patients with neuromyelitis optica and to characterize the anti-AQP4 antibodies. DESIGN We compared a simple new quantitative fluorescence immunoprecipitation assay (FIPA) with both indirect immunofluorescence and an AQP4… CONTINUE READING

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