Aquaporin-4 Deficiency Impairs Synaptic Plasticity and Associative Fear Memory in the Lateral Amygdala: Involvement of Downregulation of Glutamate Transporter-1 Expression

@article{Li2012Aquaporin4DI,
  title={Aquaporin-4 Deficiency Impairs Synaptic Plasticity and Associative Fear Memory in the Lateral Amygdala: Involvement of Downregulation of Glutamate Transporter-1 Expression},
  author={Yan-kun Li and Fang Wang and Wei Wang and Yi Luo and Peng-Fei Wu and Jun-Li Xiao and Zhuang-li Hu and You Ju Jin and Gang Hu and J Chen},
  journal={Neuropsychopharmacology},
  year={2012},
  volume={37},
  pages={1867-1878}
}
Astrocytes are implicated in information processing, signal transmission, and regulation of synaptic plasticity. Aquaporin-4 (AQP4) is the major water channel in adult brain and is primarily expressed in astrocytes. A growing body of evidence indicates that AQP4 is a potential molecular target for the regulation of astrocytic function. However, little is known about the role of AQP4 in synaptic plasticity in the amygdala. Therefore, we evaluated long-term potentiation (LTP) in the lateral… CONTINUE READING
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Neuroglia, 2nd edn

  • H Kettenmann, BR Ransom
  • Oxford University Press: New York, p. xix, 601pp.
  • 2005
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