Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis.

@article{Harachikuma2015Aquaporin3mediatedHP,
  title={Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis.},
  author={Mariko Hara-chikuma and Hiroki Satooka and Sachiko Watanabe and Tetsuya Honda and Yoshiki Miyachi and Takeshi Watanabe and Alan S. Verkman},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={
          7454
        }
}
Aquaporin 3 (AQP3), a water/glycerol channel protein, has been found to transport hydrogen peroxide (H2O2). Here, we show that H2O2, imported via AQP3, is involved in nuclear factor-κB (NF-κB) signalling in keratinocytes and in the pathogenesis of psoriasis. IL-23-mediated induction of psoriasis is reduced in AQP3 knockout mice (AQP3(-/-)), and is accompanied by impaired NF-κB activation and intracellular H2O2 accumulation. In primary keratinocyte cultures, cellular import of H2O2 produced by… CONTINUE READING
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