Aquaporin-2 regulation by vasopressin in the rat inner ear.

  title={Aquaporin-2 regulation by vasopressin in the rat inner ear.},
  author={Shoichi Sawada and Taizo Takeda and Hiroya Kitano and Shunji Takeuchi and Akinobu Kakigi and Hiroshi Azuma},
  volume={13 9},
Our previous studies have suggested a close relationship between vasopressin and endolymphatic hydrops, or the increased volume of endolymph in the inner ear. Endolymphatic hydrops is also thought to occur in Ménière's disease patients. In the kidney collecting duct, vasopressin induces the expression of aquaporin-2 (AQP2), resulting in increased water reabsorption. We explored the possibility, using a quantitative PCR method, that vasopressin regulates the expression of AQP2 mRNA in the rat… CONTINUE READING
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