Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement.

@article{Stamer2003Aquaporin1CI,
  title={Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement.},
  author={William Daniel Stamer and Dean Bok and Jane C. Hu and Glenn J. Jaffe and Brian S McKay},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 6},
  pages={2803-8}
}
PURPOSE Aquaporin (AQP) is a hexahelical integral membrane protein that functions as a constitutive channel for water and regulated channel for cations in fluid transporting tissues, including many in the eye. Although AQP1 has been cloned from a cDNA library prepared from cultures of retinal pigment epithelial (RPE) cells isolated from human fetal tissue, three separate studies failed with various immunochemical techniques to detect AQP1 protein in adult human or rat RPE preparations. The… CONTINUE READING

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