Aquaglyceroporins: channel proteins with a conserved core, multiple functions, and variable surfaces.

@article{Engel2002AquaglyceroporinsCP,
  title={Aquaglyceroporins: channel proteins with a conserved core, multiple functions, and variable surfaces.},
  author={Andreas Engel and Henning Stahlberg},
  journal={International review of cytology},
  year={2002},
  volume={215},
  pages={75-104}
}
Membrane channels for water and small nonionic solutes are required for osmoregulation in bacteria, plants, and animals. Aquaporin-1, the water channel of human erythrocytes, is the first channel demonstrated to conduct water, by expression in Xenopus oocytes. Phylogenetic analyses reveal the existence of two clusters of subfamilies, the aquaporins (AQPs) and glycerol facilitators (GLPs). Sequence-based structure prediction provided a model comprising six membrane-spanning helices, while… CONTINUE READING
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