Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.

Abstract

African trypanosomes cause sleeping sickness in humans, a disease that is typically fatal without chemotherapy. Unfortunately, drug resistance is common and melarsoprol-resistant trypanosomes often display cross-resistance to pentamidine. Although melarsoprol/pentamidine cross-resistance (MPXR) has been an area of intense interest for several decades, our… (More)
DOI: 10.1073/pnas.1202885109

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