Aquagenic urticaria: evidence of cholinergic and histaminergic basis

  title={Aquagenic urticaria: evidence of cholinergic and histaminergic basis},
  author={R G Sibbald and Anne Kobza Black and R. A. J. Eady and M James and M. W. Greaves},
  journal={British Journal of Dermatology},
Two patients with urticaria evoked at the site of contact of skin with water have been studied. Protection of the skin from contact with water by prior application of petrolatum ointment prevented wealing, but removal of the stratum corneum enhanced wealing. 

New approaches in treatment of physical urticarias *

The conventional Hi antihistamines partly improve the urticarial reactions of the physical urticarias, except those of pressure urticaria, but in practice antihistamine therapy is disappointing.

Aquagenic pruritus.

The clinical presentations of urticaria.

Chronic urticaria can significantly affect the quality of life and is frequently misunderstood by patients who believe the condition is always the result of an allergy and is dangerous.

Urticaria and angioedema.

Mechanical trauma and urticaria.

  • A. Black
  • Medicine, Biology
    American journal of industrial medicine
  • 1985
Pressure may localise lesions of chronic idiopathic urticaria and Trauma may exacerbate hereditary angio-oedema.

[Aquagenic urticaria. A case report].

A 38-year-old woman presented with recurrent episodes of urticaria after contact with water affecting the upper part of the body. We confirmed the diagnosis of aquagenic urticaria. Aquagenic

Case of aquagenic urticaria: Case report and the results of histopathological examination

A 16‐year‐old Japanese boy diagnosed with Aquagenic urticaria by water provocation test is reported, and the induced skin lesion histologically showed prominent degranulation of mast cells and lymphocytic infiltration throughout the dermis.

Aquagenic Urticaria: A Perplexing Physical Phenomenon.

Aquagenic urticaria is usually symptomatic with mild to severe pruritus and a burning sensation, and the mechanism by which water produces mast cell degranulation and histamine release remains unclear.

Aquagenic Urticaria in a Child

A healthy 3-year-old boy daveloped acute urticaria five minutes after exposure to tap water in different areas of Jerusalem, the youngest patient to be reported.

Aquagenic urticaria and human immunodeficiency virus infection: treatment with stanozolol

The first case of aquagenic urticaria in a patient with human immunodeficiency virus (HIV) infection is reported, suggesting a novel indication for this anabolic steroid stanozolol.




Critical wetting of the sensitive areas of the skin surface, which triggers cholinergic urticaria, can be achieved by a few minutes immersion in a water bath, contact with distilled water, or sweating itself.

Mast cell population density, blood vessel density and histamine content in normal human skin

Mast cell population density was determined in normal skin from two regions of the arm of several healthy men and compared with blood vessel density and histamine concentration in the same sites and by automated fluorimetric analysis.

An improved perfusion fixation method for the testis

A reliable and uniform vascular perfusion fixation method for the testis has been developed by using an initial washout solution containing a vasodilator and an anticoagulant and then a second more concentrated aldehyde fixative solution containing picric acid.

A basic fuchsin and alkalinized methylene blue rapid stain for epoxy-embedded tissue.

The method is simple, rapid (total time 4-5 min), and provides sharp contrast between cellular and connective tissue components.

Mast cell population

  • 1979

Cholinergic - mediated gastric mast cell degranulation with subsequent histamine H I - and H 2 - activation in stress ulceration in rats

  • European Journal of Pharmacology
  • 1979