Aqabamycins A–G: novel nitro maleimides from a marine Vibrio species: II. Structure elucidation*

@article{Yao2010AqabamycinsAN,
  title={Aqabamycins A–G: novel nitro maleimides from a marine Vibrio species: II. Structure elucidation*},
  author={C. B. Fondja Yao and Wael Al Zereini and Serge Fotso and Heidrun Anke and Hartmut Laatsch},
  journal={The Journal of Antibiotics},
  year={2010},
  volume={63},
  pages={303-308}
}
The structures of secondary metabolites with antibacterial and cytotoxic activities produced by a marine Vibrio strain from the Red Sea were elucidated. Aqabamycin A (1a) and seven further nitro-substituted maleimide derivates named aqabamycins B–G (1b–f and 2) were obtained together with 12 known metabolites, 3-nitro-1H-indazole (3), indazole-3-carbaldehyde (4), 3-nitro-4-hydroxycinnamic acid, 4-hydroxycinnamic acid, 3-nitro-4-hydroxybenzaldehyde, phenyl-2-bis-indolylmethane (5a), turbomycin B… 

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Seven novel maleimide derivatives named aqabamycin A, B, C, D, E, F and G are described here for the first time from a natural source and vibrindole A was found to have cytotoxic activity.

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