AqF026 is a pharmacologic agonist of the water channel aquaporin-1.

  title={AqF026 is a pharmacologic agonist of the water channel aquaporin-1.},
  author={Andrea J Yool and Johann Morelle and Yvette Cnops and Jean-Marc Verbavatz and Ewan M. Campbell and Elizabeth A H Beckett and Grant W Booker and Gary Flynn and Olivier Devuyst},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={24 7},
Aquaporin-1 (AQP1) facilitates the osmotic transport of water across the capillary endothelium, among other cell types, and thereby has a substantial role in ultrafiltration during peritoneal dialysis. At present, pharmacologic agents that enhance AQP1-mediated water transport, which would be expected to increase the efficiency of peritoneal dialysis, are not available. Here, we describe AqF026, an aquaporin agonist that is a chemical derivative of the arylsulfonamide compound furosemide. In… CONTINUE READING


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