Aptazyme-based riboswitches as label-free and detector-free sensors for cofactors.

Abstract

We constructed a label-free and detector-free aptazyme-based riboswitch sensor for detecting the cofactor of the aptazyme. This riboswitch, which usually suppresses the gene expression with its anti-RBS sequence bound to the RBS of its own mRNA (OFF), activates the translation only when a cofactor is added to release the anti-RBS sequence from itself as a… (More)

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Cite this paper

@article{Ogawa2007AptazymebasedRA, title={Aptazyme-based riboswitches as label-free and detector-free sensors for cofactors.}, author={Atsushi Ogawa and Mizuo Maeda}, journal={Bioorganic & medicinal chemistry letters}, year={2007}, volume={17 11}, pages={3156-60} }