Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport.

@article{Yasuhara2016AptamersTB,
  title={Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport.},
  author={Noriko Yasuhara and Penmetcha K R Kumar},
  journal={Journal of biochemistry},
  year={2016},
  volume={160 5},
  pages={259-268}
}
The importin-α family of proteins plays an important role in the eukaryotic importin/exportin nuclear transport system. These proteins recognize a nuclear localization signal (NLS) within cargo proteins and import them into the nucleus through nuclear pores, in a process mediated by importin-β. Recent studies have shown that importin-α proteins specifically… CONTINUE READING