Aptamers Selected for Recognizing Amyloid β-Protein—A Case for Cautious Optimism

@inproceedings{Rahimi2018AptamersSF,
  title={Aptamers Selected for Recognizing Amyloid β-Protein—A Case for Cautious Optimism},
  author={Farid Rahimi},
  booktitle={International journal of molecular sciences},
  year={2018}
}
Aptamers are versatile oligonucleotide ligands used for molecular recognition of diverse targets. However, application of aptamers to the field of amyloid β-protein (Aβ) has been limited so far. Aβ is an intrinsically disordered protein that exists in a dynamic conformational equilibrium, presenting time-dependent ensembles of short-lived, metastable structures and assemblies that have been generally difficult to isolate and characterize. Moreover, despite understanding of potential… CONTINUE READING

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