Aptamers: from bench side research towards patented molecules with therapeutic applications.

@article{Majumder2009AptamersFB,
  title={Aptamers: from bench side research towards patented molecules with therapeutic applications.},
  author={Paromita Majumder and Katia N. Gomes and Henning Ulrich},
  journal={Expert opinion on therapeutic patents},
  year={2009},
  volume={19 11},
  pages={1603-13}
}
BACKGROUND RNA and DNA aptamers recognize their targets with high specificity and affinity. These aptamers can be developed against almost any target protein through iterative cycles of in vitro screening of a combinatorial oligonucleotide library for target binding. Aptamer sequences from the final pool of in vitro selection are screened for pharmacological activity and possible medical applications. METHODS Chemical modifications and improvements of the identification of aptamer selection… CONTINUE READING

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