Aptamer that binds to the gD protein of herpes simplex virus 1 and efficiently inhibits viral entry.

@article{Gopinath2012AptamerTB,
  title={Aptamer that binds to the gD protein of herpes simplex virus 1 and efficiently inhibits viral entry.},
  author={Subash C. B. Gopinath and Kyoko Hayashi and Penmetcha K. R. Kumar},
  journal={Journal of virology},
  year={2012},
  volume={86 12},
  pages={6732-44}
}
The ectodomain of the gD protein of herpes simplex viruses (HSVs) plays an important role in viral entry by binding to specific cellular coreceptors and mediating viral entry to the host cells. In the present study, we isolated RNA aptamers (aptamer-1 and aptamer-5) that specifically bind to the gD protein of HSV-1 with high affinity and are able to discriminate the gD protein of a different virus, HSV-2. Aptamer-1 efficiently interfered with the interaction between the gD protein and the HSV-1… CONTINUE READING

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