Aptamer-targeted Antigen Delivery

  title={Aptamer-targeted Antigen Delivery},
  author={Brian C Wengerter and Joseph A Katakowski and Jacob M Rosenberg and Chae Gyu Park and Steven C. Almo and Deborah Palliser and Matthew D Levy},
  booktitle={Molecular therapy : the journal of the American Society of Gene Therapy},
Effective therapeutic vaccines often require activation of T cell-mediated immunity. Robust T cell activation, including CD8 T cell responses, can be achieved using antibodies or antibody fragments to direct antigens of interest to professional antigen presenting cells. This approach represents an important advance in enhancing vaccine efficacy. Nucleic acid aptamers present a promising alternative to protein-based targeting approaches. We have selected aptamers that specifically bind the… CONTINUE READING