Aptamer selection based on inhibitory activity using an evolution-mimicking algorithm.

In order to efficiently select aptamers that bind to and inhibit proteins, we developed a method that involves screening DNA aptamers based on their inhibitory activities using an evolution-mimicking algorithm after the pre-selection by SELEX. The value of this method was demonstrated by the identification of an inhibitor of Taq DNA polymerase in a unique… CONTINUE READING



Citations per Year

206 Citations

Semantic Scholar estimates that this publication has 206 citations based on the available data.

See our FAQ for additional information.