Aptamer micelles targeting fractalkine-expressing cancer cells in vitro and in vivo.

@article{Harris2018AptamerMT,
  title={Aptamer micelles targeting fractalkine-expressing cancer cells in vitro and in vivo.},
  author={Michael A. Harris and Timothy Pearce and Thomas Pengo and Huihui Kuang and Colleen Forster and Efrosini Kokkoli},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2018},
  volume={14 1},
  pages={85-96}
}
In this work we hypothesized that the chemokine fractalkine can serve as a cancer molecular target. We engineered aptamer micelles functionalized with an outer poly(ethylene glycol) (PEG) corona, and investigated the extent and efficacy of using them as a targeting tool against fractalkine-expressing colon adenocarcinoma cells. In vitro cell binding results… CONTINUE READING