Aptamer-mediated nanoparticle-based protein labeling platform for intracellular imaging and tracking endocytosis dynamics.

@article{Chen2012AptamermediatedNP,
  title={Aptamer-mediated nanoparticle-based protein labeling platform for intracellular imaging and tracking endocytosis dynamics.},
  author={Li Qiang Chen and Sai Xiao and Ping Ping Hu and Li Peng and Jun Ma and Ling Fei Luo and Yuan Fang Li and Cheng Zhi Huang},
  journal={Analytical chemistry},
  year={2012},
  volume={84 7},
  pages={3099-110}
}
Although nanoparticles have been widely used as optical contrasts for cell imaging, the complicated prefunctionalized steps and low labeling efficiency of nanoprobes greatly inhibit their applications in cellular protein imaging. In this study, we developed a novel and general strategy that employs an aptamer not only as a recognizer for protein recognition but also as a linker for nanoreporter targeting to specifically label membrane proteins of interest and track their endocytic pathway. With… CONTINUE READING

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