Aptamer-conjugated nanoparticles for selective collection and detection of cancer cells.

@article{Herr2006AptamerconjugatedNF,
  title={Aptamer-conjugated nanoparticles for selective collection and detection of cancer cells.},
  author={Joshua K. Herr and Joshua E. Smith and Colin D. Medley and Dihua Shangguan and Weihong Tan},
  journal={Analytical chemistry},
  year={2006},
  volume={78 9},
  pages={2918-24}
}
We have developed a method for the rapid collection and detection of leukemia cells using a novel two-nanoparticle assay with aptamers as the molecular recognition element. An aptamer sequence was selected using a cell-based SELEX strategy in our laboratory for CCRF-CEM acute leukemia cells that, when applied in this method, allows for specific recognition of the cells from complex mixtures including whole blood samples. Aptamer-modified magnetic nanoparticles were used for target cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

Similar Papers

Loading similar papers…