Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy.

@article{Chang2011AptamerconjugatedDI,
  title={Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy.},
  author={Microsugar Chang and Chung-Shi Yang and Dong-ming Huang},
  journal={ACS nano},
  year={2011},
  volume={5 8},
  pages={6156-63}
}
DNA can be used to nanofabricate three-dimensional (3D) polyhedra. A variety of applications of 3D DNA assemblies have been proposed. Drug encasulation and intracellular delivery using DNA nanoparticles, however, have remained a challenge. Here, we create a distinct five-point-star motif and aptamer-conjugated six-point-star motif using well-used primer sequences to intermolecularly construct DNA icosahedra as a nanocarrier for doxorubicin. Aptamer-conjugated doxorubicin-intercalated DNA… CONTINUE READING