Aptamer-capped nanocrystal quantum dots: a new method for label-free protein detection.

@article{Choi2006AptamercappedNQ,
  title={Aptamer-capped nanocrystal quantum dots: a new method for label-free protein detection.},
  author={Jong Hyun Choi and Kok Chen and Michael S. Strano},
  journal={Journal of the American Chemical Society},
  year={2006},
  volume={128 49},
  pages={15584-5}
}
We demonstrate that aptamer-capped near-infrared PbS quantum dots (QDs) can detect a target protein based on selective charge transfer. The water-soluble QDs are synthesized with the thrombin-binding aptamer, which retains the secondary quadruplex structure necessary for binding to thrombin. These QDs have diameters of 3-6 nm and fluoresce around 1050 nm. When the aptamer-functionalized QD binds to its target, a fluorescence quenching occurs due to charge transfer from amine groups on the… CONTINUE READING

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