Aptamer-based tumor-targeted drug delivery for photodynamic therapy.

@article{Shieh2010AptamerbasedTD,
  title={Aptamer-based tumor-targeted drug delivery for photodynamic therapy.},
  author={Y. A. Shieh and Shu-Jyuan Yang and Ming-Feng Wei and Ming-Jium Shieh},
  journal={ACS nano},
  year={2010},
  volume={4 3},
  pages={1433-42}
}
A specialized G-rich DNA structure, G-quadruplex, has been studied for its special physical characteristics and biological effects. Herein we report a novel strategy of using G-quadruplex as a drug carrier to target cancer cells for photodynamic therapy (PDT). A G-quadruplex forming AS1411 aptamer could be physically conjugated with six molecules of porphyrin derivative, 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4), to fabricate the apt-TMP complex. The TMPyP4 molecules in the… CONTINUE READING