Aptamer-based piezoelectric quartz crystal microbalance biosensor array for the quantification of IgE.

@article{Yao2009AptamerbasedPQ,
  title={Aptamer-based piezoelectric quartz crystal microbalance biosensor array for the quantification of IgE.},
  author={Chunyan Yao and Yongzhi Qi and Yuhui Zhao and Yang Xiang and Qinghai Chen and Weiling Fu},
  journal={Biosensors & bioelectronics},
  year={2009},
  volume={24 8},
  pages={2499-503}
}
The aim of this study was to develop a rapid method to measure IgE in human serum by use of a direct aptamer-based biosensor based on a quartz crystal microbalance (QCM). An avidin monolayer was applied to immobilize aptamers specific for IgE on the gold surface of a quartz crystal. The frequency shifts (FS) of the QCM were measured and related to IgE concentrations. We could demonstrate that aptamers were able to detect IgE with high specificity and sensitivity in 15 min. A linear relationship… CONTINUE READING

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