Aprotinin prolongs activated and nonactivated whole blood clotting time and potentiates the effect of heparin in vitro.

@article{Despotis1996AprotininPA,
  title={Aprotinin prolongs activated and nonactivated whole blood clotting time and potentiates the effect of heparin in vitro.},
  author={George John Despotis and Kriton S. Filos and Vladimir Levine and A L Alsoufiev and Edward W. Spitznagel},
  journal={Anesthesia and analgesia},
  year={1996},
  volume={82 6},
  pages={1126-31}
}
This study was designed to evaluate the effect of aprotinin on activated versus nonactivated whole blood clotting time using two different on-site methods and to quantify these anticoagulant properties when compared to heparin in a controlled, in vitro environment. Blood specimens were obtained prior to heparin administration from 56 patients undergoing cardiac surgery. Specimens obtained from the first consecutive 20 patients were mixed with either normal saline (NS) or aprotinin (400… CONTINUE READING

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