Aprotinin in severe acute pancreatitis.

  title={Aprotinin in severe acute pancreatitis.},
  author={Martin Smith and Hemant M. Kocher and Beverley J Hunt},
  journal={International journal of clinical practice},
  volume={64 1},
Aprotinin, a Kunitz protease inhibitor, has a wide inhibitory action with particular activity against trypsin, chymotrypsin and kallikrein, making it theoretically attractive in ameliorating the effects of acute pancreatitis. Its use in acute pancreatitis has been studied for the last 50 years with disappointing results. In this paper, we review the previous studies and argue that all the studies have not been adequately powered, have inappropriate end-points, but most importantly have not… CONTINUE READING

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