Aprotinin for primary coronary artery bypass grafting: a multicenter trial of three dose regimens.

  title={Aprotinin for primary coronary artery bypass grafting: a multicenter trial of three dose regimens.},
  author={John H Lemmer and E W Dilling and Jeremy R. Morton and Jeffrey B. Rich and Francis Robicsek and Deborah L Bricker and Charles B Hantler and Jack G. Copeland and John Lockwood Ochsner and Pat O. Daily and Charles W. Whitten and George Peter Noon and Rosemarie Maddi},
  journal={The Annals of thoracic surgery},
  volume={62 6},
  pages={1659-67; discussion 1667-8}
BACKGROUND High-dose aprotinin reduces transfusion requirements in patients undergoing coronary artery bypass grafting, but the safety and effectiveness of smaller doses is unclear. Furthermore, patient selection criteria for optimal use of the drug are not well defined. METHODS Seven hundred and four first-time coronary artery bypass grafting patients were randomized to receive one of three doses of aprotinin (high, low, and pump-prime-only) or placebo. The patients were stratified as to… CONTINUE READING


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