Aprotinin and heparin monitoring during cardiopulmonary bypass.

@article{Hunt1992AprotininAH,
  title={Aprotinin and heparin monitoring during cardiopulmonary bypass.},
  author={Beverley J Hunt and Helen C. Segal and Magdi Yacoub},
  journal={Circulation},
  year={1992},
  volume={86 5 Suppl},
  pages={II410-2}
}
BACKGROUND When high-dose aprotinin is used during cardiopulmonary bypass, there is a prolongation of the activated coagulation time (ACT), which is used to monitor heparinization. The aim of this study was to provide guidelines for monitoring heparin levels by the ACT if aprotinin is used during cardiopulmonary bypass. METHODS AND RESULTS Heparinized blood from six healthy controls and nine patients on cardiopulmonary bypass was aliquoted and mixed with various concentrations of aprotinin… CONTINUE READING