Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity

  title={Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity},
  author={Percy P Tumbale and Jessica S. Williams and Matthew J Schellenberg and T. A. Kunkel and R Scott Williams},
Faithful maintenance and propagation of eukaryotic genomes is ensured by three-step DNA ligation reactions used by ATP-dependent DNA ligases. Paradoxically, when DNA ligases encounter nicked DNA structures with abnormal DNA termini, DNA ligase catalytic activity can generate and/or exacerbate DNA damage through abortive ligation that produces chemically adducted, toxic 5′-adenylated (5′-AMP) DNA lesions. Aprataxin (APTX) reverses DNA adenylation but the context for deadenylation repair is… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 11 times over the past 90 days. VIEW TWEETS