Approved oncology drugs lack in vivo activity against Trichuris muris despite in vitro activity

@article{Cowan2016ApprovedOD,
  title={Approved oncology drugs lack in vivo activity against Trichuris muris despite in vitro activity},
  author={Noemi Cowan and A. Raimondo and Jennifer Keiser},
  journal={Parasitology Research},
  year={2016},
  volume={115},
  pages={4443-4446}
}
Infections with soil-transmitted helminths (STHs) are considered among the most persistent global health problems. The few available drugs have limitations including low efficacy against Trichuris trichiura infections. As a starting point toward drug repositioning, we studied a set of FDA-approved oncology drugs for activity against Trichuris muris since targets relevant to cancer therapy might have a function in helminth biology. Drugs were tested in vitro on the larval and adult stage of T… 
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Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing
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Sertraline, paroxetine, and chlorpromazine have long histories of use clinically as antidepressant or antipsychotic medicines and may represent new classes of anthelmintic drug that could be used in combination with existing front-line drugs to boost effectiveness of anti-parasite treatment as well as offset the development of parasite drug resistance.

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