Approved Drug Mimics of Short Peptide Ligands from Protein Interaction Motifs

@article{Parthasarathi2008ApprovedDM,
  title={Approved Drug Mimics of Short Peptide Ligands from Protein Interaction Motifs},
  author={Laavanya Parthasarathi and Fergal P. Casey and Amelie Stein and Patrick Aloy and Denis C. Shields},
  journal={Journal of chemical information and modeling},
  year={2008},
  volume={48 10},
  pages={
          1943-8
        }
}
Most biological functions are regulated through complex networks of transient protein interactions, and, thus, finding effective ways to modulate them would represent an important step towards defining the next generation of drugs. In this study, we set out to determine if existing approved drugs may represent a good source of compounds from which initial lead inhibitors of protein-protein interactions mediated by short peptide regions may be drawn. Peptide structures were defined in terms of… CONTINUE READING

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