Appropriating microbial catabolism: a proposal to treat and prevent neurodegeneration

  • Aubrey D.N.J
  • Published 2005


Intraneuronal, largely proteinaceous aggregates accumulate in all major neurodegenerative disorders. Lysosomal degradation of proteinaceous and other material declines early in such diseases. This suggests that intraneuronal aggregates consist of material which is normally broken down in the lysosome and thus accumulates when lysosomal degradation fails… (More)


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