Approaching the RNA ligand for RIG-I?

  title={Approaching the RNA ligand for RIG-I?},
  author={Martin Schlee and Evelyn Hartmann and Christoph Coch and Vera Wimmenauer and Markus Janke and Winfried Barchet and Gunther Hartmann},
  journal={Immunological reviews},
  volume={227 1},
Innate and antigen-specific antiviral immunity are triggered by immunorecognition of viral nucleic acids. The helicase retinoic acid-inducible gene I (RIG-I) (also known as DDX58) is the key sensor of negative strand RNA viruses in the cytosol of cells. RNA containing a triphosphate at the 5'-end was shown to activate RIG-I, but the exact structure of RNA supporting 5'-triphosphate recognition, the requirement of a 5'-triphosphate group, as well as the existence of RNA structures detected by… CONTINUE READING
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