Approaching the RNA ligand for RIG-I?

@article{Schlee2009ApproachingTR,
  title={Approaching the RNA ligand for RIG-I?},
  author={Martin Schlee and Evelyn Hartmann and Christoph Coch and Vera Wimmenauer and Markus Janke and Winfried Barchet and Gunther Hartmann},
  journal={Immunological reviews},
  year={2009},
  volume={227 1},
  pages={66-74}
}
Innate and antigen-specific antiviral immunity are triggered by immunorecognition of viral nucleic acids. The helicase retinoic acid-inducible gene I (RIG-I) (also known as DDX58) is the key sensor of negative strand RNA viruses in the cytosol of cells. RNA containing a triphosphate at the 5'-end was shown to activate RIG-I, but the exact structure of RNA supporting 5'-triphosphate recognition, the requirement of a 5'-triphosphate group, as well as the existence of RNA structures detected by… CONTINUE READING
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Loss of DExD ⁄ H box poly(I:C)

  • T Venkataraman
  • Adv Drug Deliv Rev 2008;60: 805–812
  • 2007
Highly Influential
8 Excerpts

Differential roles of MDA5

  • H Kato
  • 2006
Highly Influential
8 Excerpts

Essential role of IPS-1 in 994–997. innate immune responses against RNA

  • H Kumar
  • J Exp Med
  • 2006
Highly Influential
5 Excerpts

IPS-1, an adaptor triggering PLoS ONE 2007;2:e279. RIG-I- and Mda5-mediated type I interferon

  • T Kawai
  • Nat Immunol 2005;6:981–988. the ligand for RIG-I…
  • 2006
Highly Influential
5 Excerpts

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

  • L Gitlin
  • Proc Natl Acad Sci USA 2006;103:8459–8464
  • 2009

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