Approaching low liver iron burden in chelated patients with non-transfusion-dependent thalassemia: the safety profile of deferasirox

@inproceedings{Taher2014ApproachingLL,
  title={Approaching low liver iron burden in chelated patients with non-transfusion-dependent thalassemia: the safety profile of deferasirox},
  author={Ali T Taher and John B. Porter and Vip Viprakasit and Antonis Kattamis and Suporn Chuncharunee and Pranee Sutcharitchan and Noppadol Siritanaratkul and Raffaella Origa and Zeynep Karakaş and Dany Habr and Zewen Zhu and Maria Domenica Cappellini},
  booktitle={European journal of haematology},
  year={2014}
}
OBJECTIVE Patients with non-transfusion-dependent thalassemia (NTDT) often develop iron overload and related complications, and may require iron chelation. However, the risk of over-chelation emerges as patients reach low, near-normal body iron levels and dose adjustments may be needed. In the THALASSA study, the threshold for chelation interruption was LIC <3 mg Fe/g dw (LIC<3); 24 patients receiving deferasirox for up to 2 yr reached this target. A post hoc analysis was performed to… CONTINUE READING
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