Approaches to the treatment of Philadelphia-positive acute lymphoblastic leukemia.

@article{Grigg1993ApproachesTT,
  title={Approaches to the treatment of Philadelphia-positive acute lymphoblastic leukemia.},
  author={Andrew Grigg},
  journal={Bone marrow transplantation},
  year={1993},
  volume={12 5},
  pages={431-5}
}
Philadelphia positivity occurs in 20-25% of adult patients with ALL, the incidence increasing with age. 'Lymphoid-type' and 'stem cell-type' subgroups have been identified. Conventional chemotherapy is ineffective in eradicating the disease in the vast majority of patients. Allogeneic BMT is the only treatment currently available which offers a reasonable prospect of cure, with a 2 year actuarial survival of approximately 40% reported for patients transplanted in first remission or after… CONTINUE READING