Approaches to the replacement of ethinylestradiol by natural 17beta-estradiol in combined oral contraceptives.

@article{Hoffmann1998ApproachesTT,
  title={Approaches to the replacement of ethinylestradiol by natural 17beta-estradiol in combined oral contraceptives.},
  author={Heather Hoffmann and Claudia B Moore and Holger Zimmermann and Walter Elger and Siegfried Schwarz and Thomas Graeser and Michel Oettel},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={1998},
  volume={50 4-6},
  pages={458-64}
}
The strong hepatic estrogenic actions of ethinylestradiol (EE) are very likely to be the cause of the cardiovascular morbidity related to the use of combined oral contraceptives (COCs). This survey presents results of EE replacement in COCs with natural 17beta-estradiol (E2) in the following stages: reduction of EE to daily doses of 0.01 mg and concomitant replacement with E2 (as valerate, EV), complete replacement of EE with E2 using a novel multiphasic combination containing EV and the… CONTINUE READING