Approaches to study of ischemia in bone.

  title={Approaches to study of ischemia in bone.},
  author={Howard Winet and Arthur S. L. Hsieh and Jessie Yun-Juan Bao},
  journal={Journal of biomedical materials research},
  volume={43 4},
Ischemic osteonecrosis is a complication of certain traumatic and a number of idiopathic conditions. The course of the disease may result in collapse of the convex member of a joint and osteoarthritis, often requiring arthroplasty. Increasing incidence in young adults poses a challenge for development of long-term joint prostheses. Current status of research into the disease is discussed and three new models using intravital microscopy described. The first, an arterial occlusion (AO) model… CONTINUE READING
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