Approaches to integrating germline and tumor genomic data in cancer research.

Abstract

Cancer is characterized by a diversity of genetic and epigenetic alterations occurring in both the germline and somatic (tumor) genomes. Hundreds of germline variants associated with cancer risk have been identified, and large amounts of data identifying mutations in the tumor genome that participate in tumorigenesis have been generated. Increasingly, these… (More)
DOI: 10.1093/carcin/bgu165

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