Approaches to deorphanization of human and microbial cytochrome P450 enzymes.

Abstract

One of the general problems in biology today is that we are characterizing genomic sequences much faster than identifying the functions of the gene products, and the same problem exists with cytochromes P450 (P450). One fourth of the human P450s are not well-characterized and therefore considered "orphans." A number of approaches to deorphanization are… (More)
DOI: 10.1016/j.bbapap.2010.05.005

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