Approaches to cutaneous wound healing: basics and future directions

  title={Approaches to cutaneous wound healing: basics and future directions},
  author={Ruijie Zeng and Chuan-Hsiung Lin and Ze Lin and Hong Yu Chen and Weiye Lu and Changmin Lin and Haihong Li},
  journal={Cell and Tissue Research},
AbstractThe skin provides essential functions, such as thermoregulation, hydration, excretion and synthesis of vitamin D. Major disruptions of the skin cause impairment of critical functions, resulting in high morbidity and death, or leave one with life-changing cosmetic damage. Due to the complexity of the skin, diverse approaches are needed, including both traditional and advanced, to improve cutaneous wound healing. Cutaneous wounds undergo four phases of healing. Traditional management… 
Advances in Skin Tissue Bioengineering and the Challenges of Clinical Translation
Insight is provided into the challenges faced by surgeons and scientists to develop new therapies and deliver the results of translational research to improve patient care and the reasons for the few available commercial skin substitutes are elucidated.
Lipid Nanoparticles As A Skin Wound Healing Drug Delivery System: Discoveries And Advances.
An update on topical formulations based on Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) as wound healing treatments is provided, able to increase solubility and stability of active pharmaceutical ingredients, and to increase skin penetration compared to the free drugs.
Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing.
This review focuses on skin structure, the dynamic process of wound healing in injured skin, and existing wound care approaches and the active role of bioactive glasses in wound repair and regeneration.
Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis.
A sericin-based hydrogel as a wound dressing for full-thickness skin injury repair is developed and the functional roles of sericIn hydrogels in promoting scarless skin regeneration along with effective recovery of skin appendages are uncovered, and seric in's potential for skin wound healing is unveiled.
Antimicrobial Peptides: The Promising Therapeutics for Cutaneous Wound Healing.
The present study discusses the types, properties and formulation strategies of AMPs used for wound healing and the challenges and opportunities for further development and utilization of AMP formulations in wound healing are discussed.
The Use of Menthol in Skin Wound Healing—Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization
Menthol presented skin wound healing activity by modulating the antioxidant system of the cells and the inflammatory response, in addition to stimulating epithelialization, as well as the mechanisms involved in its effect, according to the phases of wound healing.
SkinDot: A modified full-skin transplantation technique.
  • C. Ottoman, G. Buntrock, A. Bayer
  • Medicine
    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • 2019
Current Insight of Printability Quality Improvement Strategies in Natural-Based Bioinks for Skin Regeneration and Wound Healing
This review aims to identify the limitations raised by using natural-based bioinks and the optimum temperature for various applied printing techniques and the properties required for an ideal bioinks design for better scaffold printability.
Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin
This review aims at providing the reader with a comprehensive analysis of the most recent findings on silk fibroin, presenting studies and results demonstrating its effective role in wound healing and its great potential for wound healing applications.


Dermagraft: Use in the Treatment of Chronic Wounds.
Dermagraft is a sterile, cryopreserved, human fibroblast-derived dermal substitute generated by the culture of neonatal dermal fibroblasts onto a bioabsorbable polyglactin mesh scaffold, creating three-dimensional human tissue containing metabolically active living cells.
Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments.
Strong evidence pointing to the favorable healing of wounds in a wet or moist environment compared to dry treatment will extend the clinical indications for this treatment, and further advances are required to elucidate by which this microenvironment can be optimized to improve the healing outcome.
The use of hyaluronic acid based dressings to treat burns: A review
The currently available clinical experience suggests that these hyaluronic acid medical devices represent a safe therapeutic method useful for the treatment of acute wounds.
Application of stems cells in wound healing—An update
  • M. Teng, Yuesheng Huang, Hengshu Zhang
  • Biology, Medicine
    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2014
Recent research on various types of stem cell‐based strategies applied to improve wound healing are summarized and its apparent advantages, limitations and challenges are discussed.
Tissue-Engineered Skin Substitutes
Commonly used skin substitutes include semisynthetic dermal scaffolds, allogenic cell constructs, and cellular and decellularized allogenic or xenogenic sources.
Review Paper: Burn Coverage Technologies: Current Concepts and Future Directions
The primary goal of treatment of burn wounds are the rapid wound closure and a functional and aesthetically satisfactory scar.
Epidermal Healing in Burns: Autologous Keratinocyte Transplantation as a Standard Procedure: Update and Perspective
Cell suspensions transplanted directly to the wound is an attractive process, removing the need for attachment to a membrane before transfer and avoiding one potential source of inefficiency.
Stem Cell-Based Therapeutics to Improve Wound Healing
Scientific inquiry into stem cell-based wound therapy abounds in research labs around the world, and the heavy investment in their potential makes it a worthwhile subject to review for plastic surgeons, in terms of both their current and future applications.
Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential
The body of evidence suggesting that MSC accelerate wound healing in both clinical and preclinical studies is examined and also the possible mechanisms controlling its efficacy are examined.
Comparison of Dermal Substitutes in Wound Healing Utilizing a Nude Mouse Model
While all dermal substitutes were incorporated into the wound bed and wound contracture was decreased, acellular dermal matrix and Alloderm produced less contraction and the thickest new “dermis” in the healed wounds compared to the control or synthetic dermal substitute.