Approaches to acute liver failure in children.

  title={Approaches to acute liver failure in children.},
  author={Anil Dhawan and Paul Cheeseman and Giorgina Mieli-Vergani},
  journal={Pediatric transplantation},
  volume={8 6},
Acute liver failure (ALF) is a rare but often fatal disorder in childhood. Its aetiology includes infections, toxins, metabolic disorders, infiltrative diseases, autoimmune hepatitis, ischaemia, irradiation damage, but in a high proportion of cases it remains unknown. In contrast to adults, in children with ALF hepatic encephalopathy can be a late event, and may not develop at all, despite a lethal outcome, particularly in infants. Children with ALF should be managed in experienced centres with… CONTINUE READING
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