Approaches of targeting Rho GTPases in cancer drug discovery.

@article{Lin2015ApproachesOT,
  title={Approaches of targeting Rho GTPases in cancer drug discovery.},
  author={Yuan Lin and Yi cheng Zheng},
  journal={Expert opinion on drug discovery},
  year={2015},
  volume={10 9},
  pages={991-1010}
}
INTRODUCTION Rho GTPases are master regulators of actomyosin structure and dynamics and play pivotal roles in a variety of cellular processes including cell morphology, gene transcription, cell cycle progression, and cell adhesion. Because aberrant Rho GTPase signaling activities are widely associated with human cancer, key components of Rho GTPase signaling pathways have attracted increasing interest as potential therapeutic targets. Similar to Ras, Rho GTPases themselves were, until recently… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…