Approaches for analyzing the differential activities and functions of eIF4E family members.

@article{Rhoads2007ApproachesFA,
  title={Approaches for analyzing the differential activities and functions of eIF4E family members.},
  author={Robert E. Rhoads and Tzvetanka D Dinkova and Rosemary Jagus},
  journal={Methods in enzymology},
  year={2007},
  volume={429},
  pages={
          261-97
        }
}
The translational initiation factor eIF4E binds to the m(7)G-containing cap of mRNA and participates in recruitment of mRNA to ribosomes for protein synthesis. eIF4E also functions in nucleocytoplasmic transport of mRNA, sequestration of mRNA in a nontranslatable state, and stabilization of mRNA against decay in the cytosol. Multiple eIF4E family members have been identified in a wide range of organisms that includes plants, flies, mammals, frogs, birds, nematodes, fish, and various protists… CONTINUE READING
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