Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites

@article{Diao2017ApproachesCA,
  title={Approaches, Challenges, and Advances in Metabolism of New Synthetic Cannabinoids and Identification of Optimal Urinary Marker Metabolites},
  author={X. Diao and M. Huestis},
  journal={Clinical Pharmacology & Therapeutics},
  year={2017},
  volume={101}
}
  • X. Diao, M. Huestis
  • Published 2017
  • Biology, Medicine
  • Clinical Pharmacology & Therapeutics
    • We review approaches for determining metabolism of new synthetic cannabinoids (SCs), and challenges and advances in identifying optimal urinary marker metabolites of SC intake. Metabolic patterns of different SC generations are evaluated, and a practical strategy offered for selecting SC urinary marker metabolites. Novel SCs are incubated with human hepatocytes, the most abundant and characteristic metabolites are identified with high‐resolution mass spectrometry, and proposed hepatocyte marker… CONTINUE READING
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    References

    SHOWING 1-10 OF 97 REFERENCES
    Synthetic cannabinoids pharmacokinetics and detection methods in biological matrices
    • 71
    First Characterization of AKB-48 Metabolism, a Novel Synthetic Cannabinoid, Using Human Hepatocytes and High-Resolution Mass Spectrometry
    • 68
    First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry.
    • 77
    • PDF
    Determination of AM-2201 metabolites in urine and comparison with JWH-018 abuse
    • 48
    • Highly Influential
    Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids.
    • 118
    • PDF
    Metabolism and toxicological analysis of synthetic cannabinoids in biological fluids and tissues.
    • 30
    In vivo and in vitro metabolism of the synthetic cannabinoid JWH-200.
    • 39
    Identification of AB-FUBINACA metabolites in human hepatocytes and urine using high-resolution mass spectrometry
    • 48
    4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry
    • 32
    • PDF
    Metabolism of classical cannabinoids and the synthetic cannabinoid JWH‐018
    • 20