Approach to profile proteins that recognize post-translationally modified histone "tails".

@article{Li2010ApproachTP,
  title={Approach to profile proteins that recognize post-translationally modified histone "tails".},
  author={Xiang Shu Li and Tarun M Kapoor},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 8},
  pages={2504-5}
}
Post-translational modifications (PTMs) of histones, proteins onto which DNA is packaged, are involved in many biological processes, including transcription, recombination, and chromosome segregation. As these PTMs can be dynamic, combinatorial, and mediators of weak interactions, the comprehensive profiling of all proteins that recognize histone PTMs is a daunting task. Here we describe an approach to design probes that can be used to identify proteins that directly interact with modified… CONTINUE READING

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Posttranslational Modifications of Proteins: Expanding Nature’s InVentory; Roberts and Co

C. T. Walsh
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