Approach to Merosesquiterpenes via Lewis Acid Catalyzed Nazarov-Type Cyclization: Total Synthesis of Akaol A.


A Lewis acid catalyzed Nazarov-type cyclization of arylvinylcarbinol has been developed for the asymmetric synthesis of carbotetracyclic core of merosesquiterpenes. The reaction works only in the presence of 2 mol % of Sn(OTf)2 and Bi(OTf)3 in dichloroethane under elevated temperature. The methodology offers the synthesis of a variety of enantioenriched… (More)
DOI: 10.1021/acs.orglett.6b00446


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Blog articles referencing this paper

  • Akaol A synthesis

    Naturalproductman's Blog · Apr 04, 2016

  • Don't see an article that should be here?